ENDOCRINE FUNCTION OF THE SURGICALLY REDUCED PANCREAS
نویسندگان
چکیده
منابع مشابه
Endocrine Function of the Surgically Reduced Pancreas
The pancreas reduced to 4 or 10 gm. weeks or months previously by partial resection, is able to maintain a normal glycemic level in dogs of about 10 kilos in good condition. When the pancreas is reduced to 4 gm. the capacity for secreting insulin under certain conditions of strain is diminished whereas a pancreas reduced to 10 gm. may have a normal or decreased capacity. This decreased function...
متن کاملEpigenetics in formation, function, and failure of the endocrine pancreas
BACKGROUND Epigenetics, in the broadest sense, governs all aspects of the life of any multicellular organism, as it controls how differentiated cells arrive at their unique phenotype during development and differentiation, despite having a uniform (with some exceptions such as T-cells and germ cells) genetic make-up. The endocrine pancreas is no exception. Transcriptional regulators and epigene...
متن کاملDevelopment of the endocrine pancreas.
This short review presents the recent breakthroughts in our understanding of the important steps controlling pancreas morphogenesis and differentiation, and on the transcription factors regulating pancreas organogenesis and islet cell differentiation and involved in the specification of the beta and alpha cell lineages. All these studies should permit a comprehensive view of the full genetic pr...
متن کاملGABA in the Endocrine Pancreas
-Aminobutyric acid (GABA) is a principal nonpeptidal neurotransmitter with a well-characterized role as an inhibitor of neuronal firing in the CNS (Cherubini et al., 1991; Thomas-Reetz and De Camilli, 1994). GABA is also found in other tissues, such as the endocrine pancreas (Thomas-Reetz and De Camilli, 1994). In the neuron, GABA is synthesized in close proximity to synaptic vesicles, it is pr...
متن کاملAbnormal endocrine pancreas function at birth in cystic fibrosis ferrets.
Diabetes is a common comorbidity in cystic fibrosis (CF) that worsens prognosis. The lack of an animal model for CF-related diabetes (CFRD) has made it difficult to dissect how the onset of pancreatic pathology influences the emergence of CFRD. We evaluated the structure and function of the neonatal CF endocrine pancreas using a new CFTR-knockout ferret model. Although CF kits are born with onl...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
ژورنال
عنوان ژورنال: Journal of Experimental Medicine
سال: 1941
ISSN: 1540-9538,0022-1007
DOI: 10.1084/jem.74.3.283